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1. “Including CA in the differential diagnosis for increased wall thickness”
2. “Importance of routine CA inclusion in differential diagnosis for wall thickness”
3. “Settling the score with CA: A necessary addition to differential diagnosis for wall thickness”.
It is time that CA (cardiac amyloidosis) should be routinely included in the differential diagnosis for individuals with increased wall thickness. This important message is underscored in a great editorial by Mazen Hanna and Julie Rosenthal, published in JACC Imaging. The authors highlight the significance of recognizing and diagnosing CA, as well as the potential consequences of overlooking this condition.
Cardiac amyloidosis is a rare disease characterized by the deposition of abnormal proteins, called amyloids, in the heart tissue. These amyloids can cause the walls of the heart to thicken, leading to a condition known as increased wall thickness. While CA is considered a rare disease, recent studies have shown that it may be more prevalent than previously thought, particularly among elderly individuals.
Traditionally, increased wall thickness has been associated with other conditions such as hypertrophic cardiomyopathy (HCM) or hypertension. However, the editorial by Hanna and Rosenthal argues that CA should be considered as a potential cause for increased wall thickness, especially in older patients. They emphasize the importance of including CA in the differential diagnosis to ensure early detection and appropriate management.
One of the key reasons why CA may be frequently overlooked is its nonspecific clinical presentation. The symptoms of CA can mimic those of other cardiac conditions, such as heart failure or arrhythmias. Additionally, the disease can be asymptomatic in its early stages, making it even more challenging to diagnose. This lack of specific symptoms often leads to delayed diagnosis and, consequently, delayed treatment.
The authors also highlight the importance of imaging techniques in diagnosing CA. Cardiac magnetic resonance imaging (MRI) and nuclear scintigraphy are two non-invasive methods that can provide valuable information about the presence and extent of amyloid deposits in the heart. These imaging modalities can help differentiate CA from other causes of increased wall thickness, leading to earlier and more accurate diagnosis.
In addition to the diagnostic challenges, the editorial also sheds light on the consequences of failing to include CA in the differential diagnosis. Hanna and Rosenthal emphasize that CA is a progressive disease that can lead to significant morbidity and mortality if left untreated. Early detection and appropriate management are crucial in improving outcomes for patients with CA.
The authors advocate for increased awareness among healthcare professionals, particularly cardiologists, about the possibility of CA in patients presenting with increased wall thickness. They suggest that routine inclusion of CA in the differential diagnosis can help prevent missed opportunities for early intervention and improve patient outcomes.
The editorial concludes by highlighting the need for further research and collaboration in the field of CA. Hanna and Rosenthal call for more studies to better understand the prevalence and clinical implications of CA, as well as the development of more effective diagnostic and treatment strategies.
In summary, the editorial by Mazen Hanna and Julie Rosenthal in JACC Imaging emphasizes the importance of routinely considering CA in the differential diagnosis for individuals with increased wall thickness. The authors stress the need for increased awareness, improved diagnostic techniques, and early intervention to improve outcomes for patients with CA. By settling the score with CA, healthcare professionals can help detect and manage this often-overlooked condition more effectively..
Source : @ctinocomesquita
“It is time that CA should be routinely included in the differential diagnosis for individuals with increased wall thickness”. Settling the Score With CA ∗ | JACC Imaging – Great editorial by @maz_hanna and Julie Rosenthal. #amyloidosis @dianeavilamed pic.twitter.com/L3z9XfZxvP
— Claudio Tinoco Mesquita (@ctinocomesquita) December 6, 2023
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1. Routine inclusion of CA in differential diagnosis
2. Increased wall thickness and differential diagnosis
3. Settling the score with CA in increased wall thickness diagnosis.
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